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Adaptive Subgroup Selection in Group Sequential Trials

CRAN Package

Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, doi:10.1016/j.cct.2014.09.001). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.


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  • Imports5 packages
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