ApplyPolygenicScore

Utilities for the Application of a Polygenic Score to a VCF

CRAN Package

Simple and transparent parsing of genotype/dosage data from an input Variant Call Format (VCF) file, matching of genotype coordinates to the component Single Nucleotide Polymorphisms (SNPs) of an existing polygenic score (PGS), and application of SNP weights to dosages for the calculation of a polygenic score for each individual in accordance with the additive weighted sum of dosages model. Methods are designed in reference to best practices described by Collister, Liu, and Clifton (2022) doi:10.3389/fgene.2022.818574.

  • Version3.0.1
  • R versionR (≥ 4.2.0)
  • LicenseGPL-2
  • Needs compilation?No
  • Last release03/05/2025

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  • Imports6 packages
  • Suggests3 packages