DRomics

Dose Response for Omics

CRAN Package

Several functions are provided for dose-response (or concentration-response) characterization from omics data. 'DRomics' is especially dedicated to omics data obtained using a typical dose-response design, favoring a great number of tested doses (or concentrations) rather than a great number of replicates (no need of replicates). 'DRomics' provides functions 1) to check, normalize and or transform data, 2) to select monotonic or biphasic significantly responding items (e.g. probes, metabolites), 3) to choose the best-fit model among a predefined family of monotonic and biphasic models to describe each selected item, 4) to derive a benchmark dose or concentration and a typology of response from each fitted curve. In the available version data are supposed to be single-channel microarray data in log2, RNAseq data in raw counts, or already pretreated continuous omics data (such as metabolomic data) in log scale. In order to link responses across biological levels based on a common method, 'DRomics' also handles apical data as long as they are continuous and follow a normal distribution for each dose or concentration, with a common standard error. For further details see Delignette-Muller et al (2023) doi:10.24072/pcjournal.325 and Larras et al (2018) doi:10.1021/acs.est.8b04752.


Documentation


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Insights

Last 30 days

This package has been downloaded 445 times in the last 30 days. Enough downloads to make a small wave in the niche community. The curiosity is spreading! The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 8 times.

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0 downloadsFeb 9, 2025
0 downloadsFeb 10, 2025
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25 downloadsFeb 15, 2025
14 downloadsFeb 16, 2025
22 downloadsFeb 17, 2025
9 downloadsFeb 18, 2025
30 downloadsFeb 19, 2025
42 downloadsFeb 20, 2025
23 downloadsFeb 21, 2025
6 downloadsFeb 22, 2025
15 downloadsFeb 23, 2025
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5 downloadsFeb 25, 2025
28 downloadsFeb 26, 2025
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6 downloadsFeb 28, 2025
13 downloadsMar 1, 2025
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8 downloadsMar 3, 2025
11 downloadsMar 4, 2025
38 downloadsMar 5, 2025
9 downloadsMar 6, 2025
6 downloadsMar 7, 2025
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4 downloadsMar 9, 2025
7 downloadsMar 10, 2025
12 downloadsMar 11, 2025
8 downloadsMar 12, 2025
22 downloadsMar 13, 2025
7 downloadsMar 14, 2025
29 downloadsMar 15, 2025
8 downloadsMar 16, 2025
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0 downloadsMar 22, 2025
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The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 5,192 times in the last 365 days. That's a lot of interest! Someone might even write a blog post about it. The day with the most downloads was Oct 02, 2024 with 67 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Data provided by CRAN


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Dependencies

  • Imports3 packages
  • Suggests12 packages