GeneSelectR

The workflow is a versatile R package designed for comprehensive feature selection in bulk RNAseq datasets. Its key innovation lies in the seamless integration of the 'Python' 'scikit-learn' (https://scikit-learn.org/stable/index.html) machine learning framework with R-based bioinformatics tools. 'GeneSelectR' performs robust Machine Learning-driven (ML) feature selection while leveraging 'Gene Ontology' (GO) enrichment analysis as described by Thomas PD et al. (2022) (doi:10.1002/pro.4218), using 'clusterProfiler' (Wu et al., 2021) (doi:10.1016/j.xinn.2021.100141) and semantic similarity analysis powered by 'simplifyEnrichment' (Gu, Huebschmann, 2021) (doi:10.1016/j.gpb.2022.04.008). This combination of methodologies optimizes computational and biological insights for analyzing complex RNAseq datasets.

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