GxEprs

Genotype-by-Environment Interaction in Polygenic Score Models

CRAN Package

A novel PRS model is introduced to enhance the prediction accuracy by utilising GxE effects. This package performs Genome Wide Association Studies (GWAS) and Genome Wide Environment Interaction Studies (GWEIS) using a discovery dataset. The package has the ability to obtain polygenic risk scores (PRSs) for a target sample. Finally it predicts the risk values of each individual in the target sample. Users have the choice of using existing models Li et al., 2015, Pandis et al., 2013, Peyrot et al., 2018 and Song et al., 2022, as well as newly proposed models for genomic risk prediction (refer to the URL for more details).


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