MLML2R

Maximum Likelihood Estimation of DNA Methylation and Hydroxymethylation Proportions

CRAN Package

Maximum likelihood estimates (MLE) of the proportions of 5-mC and 5-hmC in the DNA using information from BS-conversion, TAB-conversion, and oxBS-conversion methods. One can use information from all three methods or any combination of two of them. Estimates are based on Binomial model by Qu et al. (2013) doi:10.1093/bioinformatics/btt459 and Kiihl et al. (2019) doi:10.1515/sagmb-2018-0031.


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