MetaSubtract

Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results

CRAN Package

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. 'MetaSubtract' will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers. See for application: Nolte I.M. et al. (2017); doi:10.1038/ejhg.2017.50.


Documentation


Team


Insights

Last 30 days

This package has been downloaded 223 times in the last 30 days. More than a random curiosity, but not quite a blockbuster. Still, it's gaining traction! The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 8 times.

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0 downloadsMar 2, 2025
9 downloadsMar 3, 2025
10 downloadsMar 4, 2025
20 downloadsMar 5, 2025
3 downloadsMar 6, 2025
3 downloadsMar 7, 2025
1 downloadsMar 8, 2025
1 downloadsMar 9, 2025
10 downloadsMar 10, 2025
10 downloadsMar 11, 2025
3 downloadsMar 12, 2025
2 downloadsMar 13, 2025
2 downloadsMar 14, 2025
21 downloadsMar 15, 2025
2 downloadsMar 16, 2025
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5 downloadsMar 18, 2025
11 downloadsMar 19, 2025
10 downloadsMar 20, 2025
15 downloadsMar 21, 2025
8 downloadsMar 22, 2025
4 downloadsMar 23, 2025
29 downloadsMar 24, 2025
3 downloadsMar 25, 2025
1 downloadsMar 26, 2025
3 downloadsMar 27, 2025
18 downloadsMar 28, 2025
6 downloadsMar 29, 2025
2 downloadsMar 30, 2025
1 downloadsMar 31, 2025
8 downloadsApr 1, 2025
0 downloadsApr 2, 2025
0 downloadsApr 3, 2025
0 downloadsApr 4, 2025
0 downloadsApr 5, 2025
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The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 2,889 times in the last 365 days. That's enough downloads to impress a room full of undergrads. A commendable achievement indeed. The day with the most downloads was Sep 11, 2024 with 39 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Data provided by CRAN


Binaries