CRAN/E | ReAD

ReAD

Powerful Replicability Analysis of Genome-Wide Association Studies

Installation

About

A robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

Key Metrics

Version 1.0.1
Published 2023-06-30 349 days ago
Needs compilation? yes
License GPL-3
CRAN checks ReAD results

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Maintainer

Maintainer

Yan Li

Authors

Yan Li

aut / cre / cph

Haochen lei

aut

Xiaoquan Wen

aut

Hongyuan Cao

aut

Material

Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-develnot available

x86_64

r-releasenot available

x86_64

r-oldrelnot available

x86_64

Depends

Rcpp ≥ 1.0.10
qvalue

LinkingTo

Rcpp
RcppArmadillo