CRAN/E | RefBasedMI

RefBasedMI

Reference-Based Imputation for Longitudinal Clinical Trials with Protocol Deviation

Installation

About

Imputation of missing numerical outcomes for a longitudinal trial with protocol deviations. The package uses distinct treatment arm-based assumptions for the unobserved data, following the general algorithm of Carpenter, Roger, and Kenward (2013) doi:10.1080/10543406.2013.834911, and the causal model of White, Royes and Best (2020) doi:10.1080/10543406.2019.1684308. Sensitivity analyses to departures from these assumptions can be done by the Delta method of Roger. The program is derived from the 'mimix' 'Stata' package written by Suzie Cro, with additional coding for the causal model and delta method. The reference-based methods are jump to reference (J2R), copy increments in reference (CIR), copy reference (CR), and the causal model, all of which must specify the reference treatment arm. Other methods are missing at random (MAR) and the last mean carried forward (LMCF). Individual-specific imputation methods (and their reference groups) can be specified.

github.com/UCL/RefBasedMI

Key Metrics

Version 0.1.1
R ≥ 3.5.0
Published 2023-08-21 301 days ago
Needs compilation? no
License GPL-3
CRAN checks RefBasedMI results

Downloads

Yesterday 0
Last 7 days 4 0%
Last 30 days 17 -15%
Last 90 days 60 -24%
Last 365 days 691 +74%

Maintainer

Maintainer

Matteo Quartagno

Authors

Kevin McGrath
Ian White

Material

Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

RefBasedMI archive

Depends

R ≥ 3.5.0

Imports

data.table
Hmisc
norm2
mice
pastecs
assertthat