SimNPH

A toolkit for simulation studies concerning time-to-event endpoints with non-proportional hazards. 'SimNPH' encompasses functions for simulating time-to-event data in various scenarios, simulating different trial designs like fixed-followup, event-driven, and group sequential designs. The package provides functions to calculate the true values of common summary statistics for the implemented scenarios and offers common analysis methods for time-to-event data. Helper functions for running simulations with the 'SimDesign' package and for aggregating and presenting the results are also included. Results of the conducted simulation study are available as preprint: "A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards", Klinglmueller et al. (2023) doi:10.48550/ARXIV.2310.05622.

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