SynergyLMM
Statistical Framework for in Vivo Drug Combination Studies
A framework for evaluating drug combination effects in preclinical in vivo studies. 'SynergyLMM' provides functions to analyze longitudinal tumor growth experiments using linear mixed-effects models, perform time-dependent analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, doi:10.1371/journal.pone.0224137). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, doi:10.1007/b98882), and Gałecki and Burzykowski (2013, doi:10.1007/978-1-4614-3900-4).
- Version1.0.1
- R versionR (≥ 4.0)
- LicenseGPL (≥ 3)
- Needs compilation?No
- Last release02/07/2025
Documentation
Team
Rafael Romero-Becerra
MaintainerShow author detailsZhi Zhao
Show author detailsRolesContributorTero Aittokallio
Show author detailsRolesContributor
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Dependencies
- Imports14 packages
- Suggests4 packages