adaptIVPT

Contains functions carrying out adaptive procedures using mixed scaling approach to establish bioequivalence for in-vitro permeation test (IVPT) data. Currently, the package provides procedures based on parallel replicate design and balanced data, according to the U.S. Food and Drug Administration's "Draft Guidance on Acyclovir" . Potvin et al. (2008) provides the basis for our adaptive design (see Method B). For a comprehensive overview of the method, refer to Lim et al. (2023) . This package reflects the views of the authors and should not be construed to represent the views or policies of the U.S. Food and Drug Administration.

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