adestr

Methods to evaluate the performance characteristics of various point and interval estimators for optimal adaptive two-stage designs as described in Meis et al. (2024) doi:10.1002/sim.10020. Specifically, this package is written to work with trial designs created by the 'adoptr' package (Kunzmann et al. (2021) doi:10.18637/jss.v098.i09; Pilz et al. (2021) doi:10.1002/sim.8953). Apart from the a priori evaluation of performance characteristics, this package also allows for the evaluation of the implemented estimators on real datasets, and it implements methods to calculate p-values.

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