bfboinet
Backfill Bayesian Optimal Interval Design Using Efficacy and Toxicity
The backfill Bayesian optimal interval design using efficacy and toxicity outcomes for dose optimization (BF-BOIN-ET) design is a novel clinical trial design to allow patients to be backfilled at lower doses during a dose-finding trial while prioritizing the dose-escalation cohort to explore a higher dose. The advantages compared to the other designs in terms of the percentage of correct optimal dose (OD) selection, reducing the sample size, and shortening the duration of the trial, in various realistic setting.
- Version0.1.0
- R versionunknown
- LicenseGPL-3
- Needs compilation?No
- Last release11/18/2024
Team
Jing Zhu
Kentaro Takeda
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- Imports5 packages