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The beta-binomial test is used for significance analysis of independent samples by Pham et al. (2010) doi:10.1093/bioinformatics/btp677. The inverted beta-binomial test is used for paired sample testing, e.g. pre-treatment and post-treatment data, by Pham and Jimenez (2012) doi:10.1093/bioinformatics/bts394.

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