cvcrand

Constrained randomization by Raab and Butcher (2001) is suitable for cluster randomized trials (CRTs) with a small number of clusters (e.g., 20 or fewer). The procedure of constrained randomization is based on the baseline values of some cluster-level covariates specified. The intervention effect on the individual outcome can then be analyzed through clustered permutation test introduced by Gail, et al. (1996) . Motivated from Li, et al. (2016) , the package performs constrained randomization on the baseline values of cluster-level covariates and clustered permutation test on the individual-level outcomes for cluster randomized trials.

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