dtpcrm
Dose Transition Pathways for Continual Reassessment Method
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) doi:10.1158/1078-0432.CCR-17-0582. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
- Version0.1.1
- R versionunknown
- LicenseGPL-2
- LicenseGPL-3
- Needs compilation?No
- Last release08/20/2019
Documentation
Team
Christina Yap
Kristian Brock
Show author detailsRolesAuthorYi Pan
Show author detailsRolesAuthorDaniel Slade
Show author detailsRolesAuthor
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