escalation

A Modular Approach to Dose-Finding Clinical Trials

CRAN Package

Methods for working with dose-finding clinical trials. We provide implementations of many dose-finding clinical trial designs, including the continual reassessment method (CRM) by O'Quigley et al. (1990) doi:10.2307/2531628, the toxicity probability interval (TPI) design by Ji et al. (2007) doi:10.1177/1740774507079442, the modified TPI (mTPI) design by Ji et al. (2010) doi:10.1177/1740774510382799, the Bayesian optimal interval design (BOIN) by Liu & Yuan (2015) doi:10.1111/rssc.12089, EffTox by Thall & Cook (2004) doi:10.1111/j.0006-341X.2004.00218.x; the design of Wages & Tait (2015) doi:10.1080/10543406.2014.920873, and the 3+3 described by Korn et al. (1994) doi:10.1002/sim.4780131802. All designs are implemented with a common interface. We also offer optional additional classes to tailor the behaviour of all designs, including avoiding skipping doses, stopping after n patients have been treated at the recommended dose, stopping when a toxicity condition is met, or demanding that n patients are treated before stopping is allowed. By daisy-chaining together these classes using the pipe operator from 'magrittr', it is simple to tailor the behaviour of a dose-finding design so it behaves how the trialist wants. Having provided a flexible interface for specifying designs, we then provide functions to run simulations and calculate dose-paths for future cohorts of patients.


Documentation


Team


Insights

Last 30 days

This package has been downloaded 288 times in the last 30 days. More than a random curiosity, but not quite a blockbuster. Still, it's gaining traction! The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 7 times.

Sun
Mon
Tue
Wed
Thu
Fri
Sat
0 downloadsMar 2, 2025
0 downloadsMar 3, 2025
0 downloadsMar 4, 2025
31 downloadsMar 5, 2025
4 downloadsMar 6, 2025
6 downloadsMar 7, 2025
3 downloadsMar 8, 2025
3 downloadsMar 9, 2025
9 downloadsMar 10, 2025
10 downloadsMar 11, 2025
8 downloadsMar 12, 2025
4 downloadsMar 13, 2025
4 downloadsMar 14, 2025
21 downloadsMar 15, 2025
7 downloadsMar 16, 2025
9 downloadsMar 17, 2025
10 downloadsMar 18, 2025
14 downloadsMar 19, 2025
14 downloadsMar 20, 2025
15 downloadsMar 21, 2025
7 downloadsMar 22, 2025
8 downloadsMar 23, 2025
13 downloadsMar 24, 2025
10 downloadsMar 25, 2025
5 downloadsMar 26, 2025
10 downloadsMar 27, 2025
17 downloadsMar 28, 2025
3 downloadsMar 29, 2025
4 downloadsMar 30, 2025
4 downloadsMar 31, 2025
17 downloadsApr 1, 2025
11 downloadsApr 2, 2025
7 downloadsApr 3, 2025
0 downloadsApr 4, 2025
0 downloadsApr 5, 2025
3
31

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 4,065 times in the last 365 days. Consider this 'mid-tier influencer' status—if it were a TikTok, it would get a nod from nieces and nephews. The day with the most downloads was Sep 11, 2024 with 46 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Data provided by CRAN


Binaries


Dependencies

  • Depends1 package
  • Imports18 packages
  • Suggests3 packages