funreg

Performs functional regression, and some related approaches, for intensive longitudinal data (see the book by Walls & Schafer, 2006, Models for Intensive Longitudinal Data, Oxford) when such data is not necessarily observed on an equally spaced grid of times. The approach generally follows the ideas of Goldsmith, Bobb, Crainiceanu, Caffo, and Reich (2011)https://doi.org/10.1198%2Fjcgs.2010.10007 and the approach taken in their sample code, but with some modifications to make it more feasible to use with long rather than wide, non-rectangular longitudinal datasets with unequal and potentially random measurement times. It also allows easy plotting of the correlation between the smoothed covariate and the outcome as a function of time, which can add additional insights on how to interpret a functional regression. Additionally, it also provides several permutation tests for the significance of the functional predictor. The heuristic interpretation of “time” is used to describe the index of the functional predictor, but the same methods can equally be used for another unidimensional continuous index, such as space along a north-south axis. Note that most of the functionality of this package has been superseded by added features after 2016 in the 'pfr' function by Jonathan Gellar, Mathew W. McLean, Jeff Goldsmith, and Fabian Scheipl, in the 'refund' package built by Jeff Goldsmith and co-authors and maintained by Julia Wrobel. The development of the funreg package in 2015 and 2016 was part of a research project supported by Award R03 CA171809-01 from the National Cancer Institute and Award P50 DA010075 from the National Institute on Drug Abuse. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse, the National Cancer Institute, or the National Institutes of Health.

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