gJLS2
A Generalized Joint Location and Scale Framework for Association Testing
An update to the Joint Location-Scale (JLS) testing framework that identifies associated SNPs, gene-sets and pathways with main and/or interaction effects on quantitative traits (Soave et al., 2015; doi:10.1016/j.ajhg.2015.05.015). The JLS method simultaneously tests the null hypothesis of equal mean and equal variance across genotypes, by aggregating association evidence from the individual location/mean-only and scale/variance-only tests using Fisher's method. The generalized joint location-scale (gJLS) framework has been developed to deal specifically with sample correlation and group uncertainty (Soave and Sun, 2017; doi:10.1111/biom.12651). The current release: gJLS2, include additional functionalities that enable analyses of X-chromosome genotype data through novel methods for location (Chen et al., 2021; doi:10.1002/gepi.22422) and scale (Deng et al., 2019; doi:10.1002/gepi.22247).
- Version0.2.0
- R version≥ 3.6.0
- LicenseGPL (≥ 3)
- Needs compilation?No
- Last release09/30/2021
Documentation
Team
Wei Deng
Lei Sun
Show author detailsRolesAuthor
Insights
Last 30 days
This package has been downloaded 151 times in the last 30 days. Now we're getting somewhere! Enough downloads to populate a lively group chat. The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 7 times.
The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.
Last 365 days
This package has been downloaded 2,025 times in the last 365 days. Now we’re talking! This work is officially 'heard of in academic circles', just like those wild research papers on synthetic bananas. The day with the most downloads was Sep 11, 2024 with 23 downloads.
The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.
Data provided by CRAN
Binaries
Dependencies
- Imports7 packages
- Suggests2 packages