getspres

An implementation of SPRE (standardised predicted random-effects) statistics in R to explore heterogeneity in genetic association meta-analyses, as described by Magosi et al. (2019) doi:10.1093/bioinformatics/btz590. SPRE statistics are precision weighted residuals that indicate the direction and extent with which individual study-effects in a meta-analysis deviate from the average genetic effect. Overly influential positive outliers have the potential to inflate average genetic effects in a meta-analysis whilst negative outliers might lower or change the direction of effect. See the 'getspres' website for documentation and examples https://magosil86.github.io/getspres/.

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