hlaR

A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database https://haplostats.org/haplostats. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' http://www.epitopes.net versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.

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