CRAN/E | nlmixr2est

nlmixr2est

Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Installation

About

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 doi:10.1007/s10928-015-9409-1). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 doi:10.1002/psp4.12052).

Citation nlmixr2est citation info
github.com/nlmixr2/nlmixr2est
nlmixr2.github.io/nlmixr2est/

Key Metrics

Version 2.2.2
R ≥ 4.0
Published 2024-05-28 132 days ago
Needs compilation? yes
License GPL (≥ 3)
CRAN checks nlmixr2est results
Language en-US

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Maintainer

Maintainer

Matthew Fidler

Authors

Matthew Fidler

aut / cre

Yuan Xiong

aut

Rik Schoemaker

aut

Justin Wilkins

aut

Wenping Wang

aut

Robert Leary

ctb

Mason McComb

ctb

Vipul Mann

aut

Mirjam Trame

ctb

Mahmoud Abdelwahab

ctb

Teun Post

ctb

Richard Hooijmaijers

aut

Hadley Wickham

ctb

Dirk Eddelbuettel

cph

Johannes Pfeifer

ctb

Robert B. Schnabel

ctb

Elizabeth Eskow

ctb

Emmanuelle Comets

ctb

Audrey Lavenu

ctb

Marc Lavielle

ctb

David Ardia

cph

Katharine Mullen

cph

Ben Goodrich

ctb

Material

NEWS
Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Old Sources

nlmixr2est archive

Depends

nlmixr2data
R ≥ 4.0

Imports

backports
checkmate
cli
graphics
knitr
lbfgsb3c
lotri
magrittr
Matrix
methods
minqa
n1qn1 ≥ 6.0.1-10
nlme
Rcpp
rex
rxode2 ≥ 2.1.3
stats
symengine
utils

Suggests

broom.mixed
crayon
data.table
devtools
digest
dplyr ≥1.1.0
generics
nloptr
qs
sys
testthat
tibble
withr
xgxr
sfsmisc
rxode2parse ≥ 2.0.19
rxode2random ≥2.1.0
minpack.lm

LinkingTo

BH
lbfgsb3c
Rcpp
RcppArmadillo ≥ 0.11.2.3.1
rxode2 ≥ 2.1.3
rxode2parse ≥ 2.0.19
rxode2random ≥ 2.1.0

Reverse Imports

babelmixr2
nlmixr2
nlmixr2extra
nlmixr2lib
nlmixr2plot
xpose.nlmixr2