nlmixr2extra

Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

CRAN Package

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 doi:10.1007/s10928-015-9409-1). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 doi:10.1002/psp4.12052). This package is for support functions like preconditioned fits doi:10.1208/s12248-016-9866-5, boostrap and stepwise covariate selection.


Documentation


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Insights

Last 30 days

This package has been downloaded 1,262 times in the last 30 days. Consider this 'mid-tier influencer' status—if it were a TikTok, it would get a nod from nieces and nephews. The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 56 times.

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109 downloadsMar 6, 2025
40 downloadsMar 7, 2025
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The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 17,199 times in the last 365 days. That's enough downloads to make it mildly famous in niche technical communities. A badge of honor! The day with the most downloads was Oct 30, 2024 with 147 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Data provided by CRAN


Binaries


Dependencies

  • Imports15 packages
  • Suggests5 packages
  • Linking To2 packages
  • Reverse Imports3 packages