nphPower

Performs combination tests and sample size calculation for fixed design with survival endpoints using combination tests under either proportional hazards or non-proportional hazards. The combination tests include maximum weighted log-rank test and projection test. The sample size calculation procedure is very flexible, allowing for user-defined hazard ratio function and considering various trial conditions like staggered entry, drop-out etc. The sample size calculation also applies to various cure models such as proportional hazards cure model, cure model with (random) delayed treatments effects. Trial simulation function is also provided to facilitate the empirical power calculation. The references for projection test and maximum weighted logrank test include Brendel et al. (2014) doi:10.1111/sjos.12059 and Cheng and He (2021) doi:10.48550/arXiv.2110.03833. The references for sample size calculation under proportional hazard include Schoenfeld (1981) doi:10.1093/biomet/68.1.316 and Freedman (1982) doi:10.1002/sim.4780010204. The references for calculation under non-proportional hazards include Lakatos (1988) doi:10.2307/2531910 and Cheng and He (2023) doi:10.1002/bimj.202100403.

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