CRAN/E | papci

papci

Prevalence Adjusted PPV Confidence Interval

Installation

About

Positive predictive value (PPV) defined as the conditional probability of clinical trial assay (CTA) being positive given Companion diagnostic device (CDx) being positive is a key performance parameter for evaluating the clinical validity utility of a companion diagnostic test in clinical bridging studies. When bridging study patients are enrolled based on CTA assay results, Binomial-based confidence intervals (CI) may are not appropriate for PPV CI estimation. Bootstrap CIs which are not restricted by the Binomial assumption may be used for PPV CI estimation only when PPV is not 100%. Bootstrap CI is not valid when PPV is 100% and becomes a single value of [1, 1]. We proposed a risk ratio-based method for constructing CI for PPV. By simulation we illustrated that the coverage probability of the proposed CI is close to the nominal value even when PPV is high and negative percent agreement (NPA) is close to 100%. There is a lack of R package for PPV CI calculation. we developed a publicly available R package along with this shiny app to implement the proposed approach and some other existing methods.

Key Metrics

Version 0.1.0
Published 2021-09-14 1121 days ago
Needs compilation? no
License GPL-3
CRAN checks papci results

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Maintainer

Maintainer

Cui Guo

Authors

Cui Guo

aut / cre / ctb

Kate

(Yueyi)

Li

aut / ctb

Lei Yang

aut / ctb

Chang Xu

aut / ctb

Material

NEWS
Reference manual
Package source

macOS

r-release

arm64

r-oldrel

arm64

r-release

x86_64

r-oldrel

x86_64

Windows

r-devel

x86_64

r-release

x86_64

r-oldrel

x86_64

Imports

dplyr
tidyverse
binom
PropCIs
ratesci
Hmisc
shiny
shinythemes
readxl
DT
stats