pathfindR
Enrichment Analysis Utilizing Active Subnetworks
Enrichment analysis enables researchers to uncover mechanisms underlying a phenotype. However, conventional methods for enrichment analysis do not take into account protein-protein interaction information, resulting in incomplete conclusions. pathfindR is a tool for enrichment analysis utilizing active subnetworks. The main function identifies active subnetworks in a protein-protein interaction network using a user-provided list of genes and associated p values. It then performs enrichment analyses on the identified subnetworks, identifying enriched terms (i.e. pathways or, more broadly, gene sets) that possibly underlie the phenotype of interest. pathfindR also offers functionalities to cluster the enriched terms and identify representative terms in each cluster, to score the enriched terms per sample and to visualize analysis results. The enrichment, clustering and other methods implemented in pathfindR are described in detail in Ulgen E, Ozisik O, Sezerman OU. 2019. pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks. Front. Genet. <doi:10.3389/fgene.2019.00858>.
- Version2.4.1
- R versionunknown
- LicenseMIT
- LicenseLICENSE
- Needs compilation?No
- pathfindR citation info
- Last release05/04/2024
Documentation
- VignetteComparing Two pathfindR Results
- VignetteIntroduction to pathfindR
- VignetteStep-by-Step Execution of the pathfindR Enrichment Workflow
- VignettepathfindR Analysis for non-Homo-sapiens organisms
- VignetteObtaining PIN and Gene Sets Data
- VignetteVisualization of pathfindR Enrichment Results
- MaterialNEWS
- In ViewsOmics
Team
Ege Ulgen
Ozan Ozisik
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Dependencies
- Depends1 package
- Imports13 packages
- Suggests3 packages