powerpkg

Power Analyses for the Affected Sib Pair and the TDT Design

CRAN Package

There are two main functions: (1) To estimate the power of testing for linkage using an affected sib pair design, as a function of the recurrence risk ratios. We will use analytical power formulae as implemented in R. These are based on a Mathematica notebook created by Martin Farrall. (2) To examine how the power of the transmission disequilibrium test (TDT) depends on the disease allele frequency, the marker allele frequency, the strength of the linkage disequilibrium, and the magnitude of the genetic effect. We will use an R program that implements the power formulae of Abel and Muller-Myhsok (1998). These formulae allow one to quickly compute power of the TDT approach under a variety of different conditions. This R program was modeled on Martin Farrall's Mathematica notebook.


Documentation


Team


Insights

Last 30 days

This package has been downloaded 201 times in the last 30 days. Enough downloads to make a small wave in the niche community. The curiosity is spreading! The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 9 times.

Sun
Mon
Tue
Wed
Thu
Fri
Sat
0 downloadsMar 2, 2025
7 downloadsMar 3, 2025
14 downloadsMar 4, 2025
12 downloadsMar 5, 2025
5 downloadsMar 6, 2025
8 downloadsMar 7, 2025
8 downloadsMar 8, 2025
2 downloadsMar 9, 2025
3 downloadsMar 10, 2025
8 downloadsMar 11, 2025
6 downloadsMar 12, 2025
12 downloadsMar 13, 2025
2 downloadsMar 14, 2025
11 downloadsMar 15, 2025
2 downloadsMar 16, 2025
7 downloadsMar 17, 2025
6 downloadsMar 18, 2025
5 downloadsMar 19, 2025
7 downloadsMar 20, 2025
7 downloadsMar 21, 2025
6 downloadsMar 22, 2025
5 downloadsMar 23, 2025
11 downloadsMar 24, 2025
3 downloadsMar 25, 2025
6 downloadsMar 26, 2025
5 downloadsMar 27, 2025
17 downloadsMar 28, 2025
1 downloadsMar 29, 2025
4 downloadsMar 30, 2025
2 downloadsMar 31, 2025
9 downloadsApr 1, 2025
0 downloadsApr 2, 2025
0 downloadsApr 3, 2025
0 downloadsApr 4, 2025
0 downloadsApr 5, 2025
1
17

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 3,063 times in the last 365 days. That's enough downloads to impress a room full of undergrads. A commendable achievement indeed. The day with the most downloads was Jul 21, 2024 with 140 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Data provided by CRAN


Binaries