prioGene

Candidate Gene Prioritization for Non-Communicable Diseases Based on Functional Information

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In gene sequencing methods, the topological features of protein-protein interaction (PPI) networks are often used, such as ToppNet https://toppgene.cchmc.org. In this study, a candidate gene prioritization method was proposed for non-communicable diseases considering disease risks transferred between genes in weighted disease PPI networks with weights for nodes and edges based on functional information.


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