qch
Query Composite Hypotheses
Provides functions for the joint analysis of Q sets of p-values obtained for the same list of items. This joint analysis is performed by querying a composite hypothesis, i.e. an arbitrary complex combination of simple hypotheses, as described in Mary-Huard et al. (2021) doi:10.1093/bioinformatics/btab592 and De Walsche et al.(2023) doi:10.1101/2024.03.17.585412. In this approach, the Q-uplet of p-values associated with each item is distributed as a multivariate mixture, where each of the 2^Q components corresponds to a specific combination of simple hypotheses. The dependence between the p-value series is considered using a Gaussian copula function. A p-value for the composite hypothesis test is derived from the posterior probabilities.
- Version2.0.0
- R versionunknown
- LicenseGPL-3
- Needs compilation?Yes
- Last release03/29/2024
Team
Tristan Mary-Huard
Annaig De Walsche
Franck Gauthier
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- Imports6 packages
- Linking To2 packages