spinBayes

Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Existing Bayesian methods for gene-environment (G×E) interaction studies are challenged by the high-dimensional nature of the study and the complexity of environmental influences. We have developed a novel and powerful semi-parametric Bayesian variable selection method that can accommodate linear and nonlinear G×E interactions simultaneously (Ren et al. (2020) doi:10.1002/sim.8434). Furthermore, the proposed method can conduct structural identification by distinguishing nonlinear interactions from main effects only case within Bayesian framework. Spike-and-slab priors are incorporated on both individual and group level to shrink coefficients corresponding to irrelevant main and interaction effects to zero exactly. The Markov chain Monte Carlo algorithms of the proposed and alternative methods are efficiently implemented in C++.

Last 30 days

This package has been downloaded 153 times in the last 30 days. Enough downloads to make a small wave in the niche community. The curiosity is spreading! The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 7 times.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 2,002 times in the last 365 days. Consider this 'mid-tier influencer' status—if it were a TikTok, it would get a nod from nieces and nephews. The day with the most downloads was Feb 11, 2025 with 39 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.