trialr

A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) doi:10.2307/2531628; EffTox by Thall & Cook (2004) doi:10.1111/j.0006-341X.2004.00218.x; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) doi:10.1002/sim.3230; and the Augmented Binary method by Wason & Seaman (2013) doi:10.1002/sim.5867; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.

Last 30 days

This package has been downloaded 451 times in the last 30 days. Now we're getting somewhere! Enough downloads to populate a lively group chat. The following heatmap shows the distribution of downloads per day. Yesterday, it was downloaded 9 times.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.

Last 365 days

This package has been downloaded 5,256 times in the last 365 days. That's a lot of interest! Someone might even write a blog post about it. The day with the most downloads was Feb 20, 2025 with 65 downloads.

The following line graph shows the downloads per day. You can hover over the graph to see the exact number of downloads per day.