grantham

A minimal set of routines to calculate the Grantham distance [doi:10.1126/science.185.4154.862]. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

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